Dose-finding Study Using Pentostatin for Injection in the Treatment of Steroid-refractory aGvHD

You may be eligible if

• Inclusion:
• Patients 6 months of age with grade 2 GVHD that is steroid-refractory
• Must be engrafted with ANC 1000/mL, may still be transfusion dependent for platelets and PRBC
• Time post stem cell infusion \< 100 days
• Written informed consent
• Must have adequate renal function (creatinine clearance 40 mL/min/1.73 m2)
• Exclusion:
• Post-transplant lymphoproliferative disease
• Uncontrolled infection
• Mental illness or other condition preventing full cooperation with the treatment and monitoring requirements of the study
• ATG within the previous 14 days
• Other immunosuppressive agents (including monoclonal antibodies) when initiated within the previous 7 days