Blood Component Collection From Patients With Rheumatic or Kidney Disease and Healthy Volunteers

Exclusion Criteria

• •History of allergy to acid-citrate-dextrose (ACD) anticoagulant
• •History of bleeding diatheses
• •Hemoglobin less than 9.0 g/dL
• •Platelet count less than 50,000/mm(3)
• •Pregnancy
• •Inadequate peripheral venous access
• •Active hepatitis B, C and/or HIV infection
• •Symptomatic coronary artery or valvular heart disease
• •Any concomitant illness that in the opinion of the investigators will substantially increase the risk of apheresis.
• •History of autoimmune or chronic rheumatic disease within the last 5 years, with the exception of osteoarthritis
• •Active hepatitis B, C, and/or HIV infection
• •History of allergy to acid-citrate (ACD) anticoagulant
• •History of coagulopathies and bleeding diatheses
• •Symptomatic coronary artery disease or valvular heart disease
• •Hemoglobin less than 12.0 g/dL
• •Platelet count less than 100,000/cubic mm
• •Pregnancy
• •Inadequate peripheral venous access
• •Any concomitant illness that in the opinion of the investigators will substantially increase the risk of apheresis or make the volunteer ineligible for study controls are needed for (eg: active infection, allergies, etc.)