Technical Development of Cardiovascular Magnetic Resonance Imaging

Exclusion Criteria

• •* Patients with a contraindication to MRI scanning will be excluded. These contraindications include patients with the following devices:
• •* Central nervous system aneurysm clips;
• •* Implanted neural stimulator;
• •* Implanted cardiac pacemaker or defibrillator;
• •* Cochlear implant;
• •* Ocular foreign body (e.g. metal shavings);
• •* Implanted Insulin pump;
• •* Metal shrapnel or bullet.
• •3. In addition, the following patient groups will be excluded:
• •* Pregnant women (Patients who are uncertain as to whether they are pregnant will be required to have a screening urine or blood pregnancy test)
• •* Patients with active symptoms of myocardial ischemia occurring despite maximally tolerated doses of oral antianginal therapy and intravenous nitroglycerin
• •4. Furthermore, the following patient groups will be excluded from studies involving the administration of MRI contrast agents:
• •* lactating women unless they are willing to discard breast milk for 24 hours after receiving gadolinium
• •* renal disease (estimated glomerular filtration rate (eGFR) less than 30 ml/min/1.73 m(2) body surface area)
• •The eGFR will be used to estimate renal function if reported by the laboratory, or as reported by NIH Clinical Center or Suburban Hospital or other clinically certified laboratories. Otherwise, estimated glomerular filtration rate (eGFR) can be based on the Modification of Diet in Renal Disease (MDRD) study equation (see below) in subjects with stable renal function. This formula is not applicable to patients with acute renal insufficiency:
• •eGFR (ml/min/1.73 m(2)) equal to 175 times (serum creatinine)-1.154 times (age)-0.203 times 0.742 (if the subject is female) times1.212 (if the subject is black)
• •* Myocardial infarction within 48 hours
• •* Uncontrolled congestive heart failure
• •* Severe hypertension (SBP greater than 200, DBP greater than 110) (exclusion only for dobutamine and bicycle)
• •* Atrial fibrillation. This exclusion only applies to Dobutamine stress.
• •* Frequent PVC s (more than 1 every 10 heart beats or non-sustained ventricular tachycardia (greater than 4 beat runs) or ongoing sustained ventricular tachycardia. This exclusion only applies to Dobutamine and Bicycle stress
• •* Patients with narrow angle glaucoma and known or suspected prostatic obstruction will not receive atropine
• •* Pregnant patients
• •* Patients that are breast feeding