Radiolabeled Monoclonal Antibody Followed by Peripheral Stem Cell Transplantation in Treating Patients With Relapsed or Metastatic Breast Cancer

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Histologically or cytologically confirmed stage IV breast cancer
• •* At least 1 site of relapse or metastatic disease
• •Progressive disease after at least 1 prior chemotherapy regimen for metastatic disease
• •* One regimen must contain an anthracycline and a taxane as adjuvant therapy or for metastatic disease
• •* Prior adjuvant chemotherapy allowed
• •Measurable or evaluable disease
• •Tumor tissue must express B3 antigen on the surface of more than 30% of tumor cells
• •No CNS metastasis
• •Hormone receptor status:
• •* Not specified
• •PATIENT CHARACTERISTICS:
• •Age:
• •18 and over
• •Sex:
• •Male or female
• •Menopausal status:
• •Not specified
• •Performance status:
• •ECOG 0-1
• •Life expectancy:
• •Not specified
• •Hematopoietic:
• •Absolute granulocyte count greater than 2,000/mm\^3
• •Platelet count greater than 100,000/mm\^3
• •Hepatic:
• •Bilirubin normal
• •SGOT and SGPT no greater than 2 times upper limit of normal
• •PT normal
• •Hepatitis B surface antigen negative
• •Hepatitis C negative
• •Renal:
• •Creatinine no greater than 1.4 mg/dL
• •Cardiovascular:
• •Ejection fraction at least 45% by MUGA or echocardiogram
• •Pulmonary:
• •FEV\_1 greater than 60% of predicted
• •FVC at least 55% of predicted
• •DLCO at least 55% of predicted
• •Other:
• •No known seizure disorders
• •No history of autoimmune disease
• •No other active malignancy except previously treated basal cell skin cancer
• •No other concurrent medical or psychiatric condition that would preclude study participation
• •HIV negative
• •Not pregnant or nursing
• •Negative pregnancy test
• •Fertile patients must use effective contraception
• •PRIOR CONCURRENT THERAPY:
• •Biologic therapy:
• •See Chemotherapy
• •No prior mouse antibody
• •Chemotherapy:
• •See Disease Characteristics
• •At least 4 weeks since prior chemotherapy (6 weeks for mitomycin or nitrosoureas) and recovered
• •No prior high-dose chemotherapy with bone marrow or stem cell transplantation
• •Endocrine therapy:
• •At least 4 weeks since prior hormonal therapy
• •No concurrent chronic steroids
• •Radiotherapy:
• •At least 4 weeks since prior local radiotherapy to one site and recovered
• •No prior radiotherapy to the pelvis and/or spine
• •Surgery:
• •Not specified
• •Other:
• •No concurrent anticoagulants