Carboxyamidotriazole in Treating Patients With Refractory or Recurrent Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cancer

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically confirmed refractory or recurrent ovarian epithelial, fallopian tube, or primary peritoneal cancer
• Measurable disease by physical exam, radiography, peritoneoscopy, or laparoscopy
• * No more than 4 weeks since prior peritoneoscopy
• No brain metastases
• PATIENT CHARACTERISTICS:
• Age:
• 18 and over
• Performance status:
• ECOG 0-2
• Life expectancy:
• At least 4 months
• Hematopoietic:
• Absolute neutrophil count at least 1,000/mm\^3
• Platelet count at least 100,000/mm\^3
• Hemoglobin at least 9.0 g/dL AND/OR
• Hematocrit at least 27%
• Hepatic:
• SGOT/SGPT no greater than 3 times upper limit of normal
• Bilirubin normal
• Renal:
• Creatinine no greater than 1.5 mg/dL OR
• Creatinine clearance at least 50 mL/min
• Cardiovascular:
• No history of symptomatic cardiac dysrhythmias requiring medication
• At least 6 months since prior myocardial infarction
• No unstable or newly diagnosed angina
• Pulmonary:
• No obstructive lung disease requiring oxygen therapy
• Other:
• Not pregnant or nursing
• HIV negative
• Must be able to take oral medication
• No concurrent medical condition (e.g., impending bowel obstruction)
• No grade 2 or greater residual peripheral neuropathy
• No active infection
• No other prior or concurrent invasive malignancy within the past 5 years
• No history of acute visual loss other than that associated with retinal detachment
• PRIOR CONCURRENT THERAPY:
• Biologic therapy:
• At least 4 weeks since prior cytokine therapy
• No concurrent cytokine therapy to maintain WBC count
• Chemotherapy:
• At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas, carboplatin, or mitomycin)
• No other concurrent chemotherapy
• Endocrine therapy:
• At least 4 weeks since prior hormonal therapy
• No concurrent corticosteroids at doses greater than physiological replacement doses
• No concurrent hormonal therapy
• Radiotherapy:
• At least 4 weeks since prior radiotherapy
• No concurrent radiotherapy
• Surgery:
• See Disease Characteristics
• Other:
• No more than 3 prior treatment regimens
• At least 1 week since prior systemic antibiotics for infection
• No chronic antifungal treatment with antimycotic imidazoles
• No concurrent alternative therapies