Adult and Juvenile Myositis

Exclusion Criteria

• •1. Patients \<2 years or \>100 years will be excluded.
• •2. Any conditions in which the drawing of the amount of blood required or undergoing procedures needed for the study is not deemed medically appropriate by the treating physician or the principal investigator.
• •For females of childbearing potential who are pregnant, they will be permitted to enroll, but would be excluded from radiographic procedures involving radiation or greater than minimal risk procedures, including obtaining biopsies.
• •Relatives of Patients with Myositis:
• •For patients with at least one first-degree relative affected with IIIM, all available first-degree relatives (affected and unaffected) are eligible to participate in the genetics portion of the protocol. For patients in which two or more first degree relatives are affected with myositis, any available close relatives (affected or unaffected parents, siblings or children, as well as grandparents and grandchildren, or other close relatives, when available) are eligible to participate in the genetics portion of the protocol.
• •1. Patients \<2 years or \>100 years will be excluded.
• •2. Any conditions in which the drawing of the amount of blood required or undergoing procedures needed for the study is not deemed medically appropriate by the treating physician or the principal investigator.
• •3. Pregnancy (females of childbearing potential). Verbal confirmation they are not pregnant.
• •Healthy Volunteers:
• •1. Volunteer has undergone surgery or had a major trauma within the past 2 months
• •2. Volunteer used anti-inflammatory medications within the past 8 weeks of enrollment, including not currently receiving nonsteroidal anti-inflammatory drugs or corticosteroids
• •3. Volunteer has been diagnosed with a chronic infectious illness, inflammatory disease, malignancy, cardiac or pulmonary disease, muscle disorder, clotting disorder, metabolic disorder, systemic rheumatic or autoimmune disease, or immune-mediated disease
• •4. Volunteer is pregnant (verbally screened for females of childbearing potential)
• •5. Volunteer has a medical illness that in the judgement of the investigators does not allow safe blood draws or other clinical evaluations needed for study participation
• •6. Volunteer is cognitively impaired
• •7. Volunteer and or the volunteer's parents/legal guardian is unable or unwilling to give informed consent/assent
• •8. Volunteer has functional limitations
• •9. Volunteer has joint or muscle problems
• •In IMAGE Survey participants must confirm in the survey that they have a medical diagnosis of myositis.
• •Note that the following screening activities may be performed to determine subject eligibility:
• •Email, written, or telephone communications with prospective subjects
• •Review of existing medical records
• •Review of existing imaging studies
• •Review of existing photographs or videos
• •Review of existing pathology specimens/reports from a specimen obtained for diagnostic purposes
• •If a participant is ineligible and willing, their contact information- including name, phone numbers, emails, best times to reach, and potential diagnosis- may be shared with other NIH investigators if the participant may be eligible to participate in those studies.