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Study of Homocysteine Metabolism in Homocystinuria | Clinical Trials | Clareo Health

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COMPLETEDNCT00004356

Study of Homocysteine Metabolism in Homocystinuria

OBJECTIVES: I. Determine basal and postmethionine plasma homocysteine in patients with premature vascular disease, cystathionine beta-synthase (CBS) or methylenetitrahydrofolate reductase (MTHFR) defi...

Lead sponsor: National Center for Research Resources (NCRR)•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

National Center for Research Resources (NCRR)

Collaborators

University of California, San Diego

PROTOCOL OUTLINE: This is a two-part study of homocysteine metabolism. Age-matched normal controls are entered in both parts of the study. In first part of the study, participants are given oral methionine; baseline and postmethionine studies include amino acid quantitation, analysis of rapidly deproteinized plasma, and total plasma homocysteine. In the second part of the study, participants (men and postmenopausal women only) undergo methionine tracer studies.

Age

0 - No limit years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•PROTOCOL ENTRY CRITERIA:
•-Disease Characteristics--
•Known or suspected homocystinuria Cystathionine beta-synthase-deficient homocystinuria Obligate heterozygotes for cystathionine beta-synthase deficiency Premature vascular disease

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: June 24, 2005Terms

Trial snapshot

StatusCOMPLETED

Phase—

Enrollment60

Start dateFeb 1995

Last updatedJun 24, 2005

Condition

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 24, 2005Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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