A Comparison of ISIS 2922 Used Immediately or Later in Patients With Cytomegalovirus (CMV) of the Eyes

Exclusion Criteria

• •Co-existing Condition:
• •Patients with the following symptoms or conditions in the eye to be treated are excluded:
• •External ocular infections.
• •Other herpetic infections of the retina, toxoplasma retinochoroiditis, or other disease of the fundus.
• •Ocular conditions that will obstruct visualization of the posterior ocular structures.
• •Retinal detachment.
• •Silicone oil in eye.
• •Patients with the following other symptoms or conditions are excluded:
• •Known or suspected allergy to phosphorothioate oligonucleotides.
• •Syphilis.
• •Pseudoretinitis pigmentosa.
• •Concurrent Medication:
• •Excluded:
• •Current treatment for extra-ocular CMV infection.
• •Ganciclovir.
• •Foscarnet.
• •Mellaril.
• •Stelazine.
• •Thorazine.
• •Clofazimine.
• •Ethambutol/fluconazole combination.
• •Investigational medications for CMV retinitis.
• •Concurrent Treatment:
• •Excluded:
• •Investigational procedures for CMV retinitis.
• •Patients with the following prior conditions are excluded:
• •History of surgery to correct retinal detachment in the eye to be treated.
• •History of syphilis.
• •Prior Medication:
• •Excluded:
• •Prior anti-CMV retinitis treatment in either eye.
• •Anti-CMV therapy for extra-ocular infection within the past 2 days.