A Comparison of Two Treatments: Pacemaker and Percutaneous Transluminal Septal Ablation for Hypertrophic Cardiomyopathy

Inclusion Criteria

• •Patients of either gender, aged 18-80 years.
• •NYHA functional class III/IV, or syncope, or greater than or equal to 2 presyncope despite verapamil and/or Beta-blocker therapy.
• •LV outflow tract gradient greater than or equal to 30 mm Hg at rest or greater than or equal to 50 mm Hg following isoproterenol infusion to a heart rate of greater than 100 bpm.
• •No patients with mid-cavity obstructive HCM.
• •No patients with LV septal wall thickness less than 15 mm estimated by echocardiography.
• •No patients with greater than 50 percent luminal narrowing in a major coronary artery vessel.
• •No patients with chronic atrial fibrillation.
• •No patients with a positive pregnancy test.