Anti-Tac(90 Y-HAT) to Treat Hodgkin's Disease, Non-Hodgkin's Lymphoma and Lymphoid Leukemia

Background: Cluster of differentiation 25 (CD25) is expressed on the malignant cells of patients with certain lymphoid malignancies as well as the non-malignant T cells that surround the malignant tumor cells of patients with Hodgkin's disease. Zenapax is a humanized monoclonal antibody that binds to CD25. Zenapax has been chemically modified by the addition of a chelating molecule to permit binding of radioactive yttrium. The yttrium labeled Zenapax binds to CD25 to deliver radiation treatment to the tumor. Objective: To assess the toxicity and therapeutic efficacy of (90)Yttrium-labeled humanized anti-Tac((90)Y-HAT) in patients with Tac-expressing hematologic malignancies. To determine the sites of localization of radiolabeled Zenapax. Eligibility: Patients with Hodgkin's disease and other CD25 positive lymphoid malignancies. The patient must have a granulocyte of at least 1,200/mm\^3 and a platelet count of greater than 100,000/mm\^3. Design: Patients will be treated with 10 mCi (if a bone marrow transplant was part of the patient's previous therapy) or 15 mCi of yttrium labeled Zenapax. Indium labeled Zenapax is given to demonstrate the antibody distribution and confirm localization at sites of tumor. Treatment is given every six weeks if tolerated and patients will be hospitalized for about one week for each treatment. Tumor response will be evaluated after every treatment. Stable or responding patients will continue treatment with evaluations after every cycle of treatment. Patients will be treated for up to seven cycles.