A Laboratory Model for Heroin Abuse Medications - 8

You may be eligible if

• Inclusion Criterion
• 1. DSM IV criteria for opioid dependence
• 2. No major mood, psychotic, or anxiety disorder
• 3. Physically healthy
• 4. Able to perform study procedures
• 5. 21-45 years of age
• 6. Current use of i.v. heroin in amounts/frequencies
• 7. Not seeking treatment for opioid dependence
• Exclusion Criterion
• 1. DSM IV criteria for dependence on drugs other
• 2. Participants requesting treatment
• 3. Participants on parole or probation
• 4. Pregnancy or lactation
• 5. Birth, miscarriage or abortion with 6 months
• 6. Recent history of or current significant violent behavior
• 7. Current major Axis I psychopathology, other than heroin dependence ( e.g., mood disorder with functional impairment or suicide risk, schizophrenia), which might interfere with ability to participate in the study
• 8. Hepatitis with SGOT or SGPT \> 3 times normal
• 9. Significant suicide risk
• 10. Current or history of chronic pain
• 11. Sensitivity, allergy, or contraindication to opioids